3D GIS Modeling of Soft Geo-Objects: Taking Rainfall, Overland Flow, and Soil Erosion as an Example

In physics, objects can be divided into rigid and soft objects according to the object deformation capacity. Similarly, geo-object can also be classified into rigid geo-objects (e.g., building, urban) and soft geo-objects (e.g., mudflow, water, soil erosion). There are three types of approaches for 3D GIS modeling, i.e., surface-based, volume-based, and hybrids in terms of geometry. These approaches are suitable for representing rigid geo-objects, but they are not suitable to simulate the intrinsic properties of the soft geo-object, i.e., dynamics and deformation. And so far there are few GIS modeling methods for simulation of soft geo-objects. GIS flow elements (FEs) and GIS soft voxels (SVs) were proposed for 3D modeling of soft geo-objects. GIS flow elements can realistically represent the dynamics and stochastics of soft geo-objects, while GIS soft voxels simulate deformation of soft geo-objects. The authors discuss the implementation and computer programming of GIS flow elements and GIS soft voxels in this study. GIS FE and SV have been successfully applied in a case study toward the simulation of the process of rainfall, overland flow, and soil erosion. A software system has been designed and developed, which has the functions of data management, model computation, and 3D simulation

Differentially Private Multi-Agent Planning for Logistic-like Problems

Planning is one of the main approaches used to improve agents' working efficiency by making plans beforehand. However, during planning, agents face the risk of having their private information leaked. This paper proposes a novel strong privacy-preserving planning approach for logistic-like problems. This approach outperforms existing approaches by addressing two challenges: 1) simultaneously achieving strong privacy, completeness and efficiency, and 2) addressing communication constraints. These two challenges are prevalent in many real-world applications including logistics in military environments and packet routing in networks. To tackle these two challenges, our approach adopts the differential privacy technique, which can both guarantee strong privacy and control communication overhead. To the best of our knowledge, this paper is the first to apply differential privacy to the field of multi-agent planning as a means of preserving the privacy of agents for logistic-like problems. We theoretically prove the strong privacy and completeness of our approach and empirically demonstrate its efficiency. We also theoretically analyze the communication overhead of our approach and illustrate how differential privacy can be used to control it

Watershed Runoff and Sediment Transport Impacts from Management Decisions Using Integrated AnnAGNPS and CCHE1D Models

Mini-Symposium: Modeling Methodology for Agricultural Researc

Development of a Novel Electromagnetic Rewarming Technology for the Cryopreservation of Stem Cells with Large Volume

Applications of stem cells have been playing significant roles in scientific and clinical settings in the last few decades. The foundation of these approaches is successful cryopreservation of stem cells for future use. However, so far we can only cryopreserve stem cell suspension of small volumes in the order of 1 mL mostly due to the lack of an effective rewarming technique. Rapid and uniform rewarming has been approved to be beneficial, and sometimes, indispensable for the survival of cryopreserved stem cells, inhibiting ice recrystallization or devitrification. Unfortunately, the conventional water bath thawing method failed in providing the rapid and uniform rewarming. The conversion of electromagnetic (EM) energy into heat provides a possible solution to this problem. This chapter will focus on (1) analysis of the combined EM and heat transfer phenomenon in the rewarming of a biospecimen, (2) numerical investigation of the rewarming system, (3) practical setup of an EM resonance system, and (4) test of heating performance with large volume of cells

Generating seamless surfaces for transport and dispersion modeling in GIS

A standard use of triangulation in GIS is to model terrain surface using TIN. In many simulation models of physical phenomena, triangulation is often used to depict the entire spatial domain, which may include buildings, landmarks and other surface objects in addition to the terrain surface. Creating a seamless surface of complex building structures together with the terrain is challenging and existing approaches are laborious, time-consuming and error-prone. We propose an efficient and robust procedure using computational geometry techniques to derive triangulated building surfaces from 2D polygon data with a height attribute. We also propose a new method to merge the resultant building surfaces with the triangulated terrain surface to produce a seamless surface for the entire study area. Using Oklahoma City data, we demonstrate the proposed method. The resultant surface is used as the input data for a simulated transport and dispersion event in Oklahoma City. The proposed method can produce the seamless surface data to be used for various types of physical models in a fraction of the time required by previous methods

Protection against SHIV-KB9 Infection by Combining rDNA and rFPV Vaccines Based on HIV Multiepitope and p24 Protein in Chinese Rhesus Macaques

Developing an effective vaccine against HIV infection remains an urgent goal. We used a DNA prime/fowlpox virus boost regimen to immunize Chinese rhesus macaques. The animals were challenged intramuscularly with pathogenic molecularly cloned SHIV-KB9. Immunogenicity and protective efficacy of vaccines were investigated by measuring IFN-γ levels, monitoring HIV-specific binding antibodies, examining viral load, and analyzing CD4/CD8 ratio. Results show that, upon challenge, the vaccine group can induce a strong immune response in the body, represented by increased expression of IFN-γ, slow and steady elevated antibody production, reduced peak value of acute viral load, and increase in the average CD4/CD8 ratio. The current research suggests that rapid reaction speed, appropriate response strength, and long-lasting immune response time may be key protection factors for AIDS vaccine. The present study contributes significantly to AIDS vaccine and preclinical research

The role of cellular senescence in metabolic diseases and the potential for senotherapeutic interventions

Cellular senescence represents an irreversible state of cell cycle arrest induced by various stimuli strongly associated with aging and several chronic ailments. In recent years, studies have increasingly suggested that the accumulation of senescent cells is an important contributor to the decline of organ metabolism, ultimately resulting in metabolic diseases. Conversely, the elimination of senescent cells can alleviate or postpone the onset and progression of metabolic diseases. Thus, a close relationship between senescent cells and metabolic diseases is found, and targeting senescent cells has emerged as an alternative therapy for the treatment of metabolic diseases. In this review, we summarize the role of cellular senescence in metabolic diseases, explore relevant therapeutic strategies for metabolic diseases by removing senescent cells, and provide new insights into the treatment of metabolic diseases